Guy Ben-Ziony grew up in Israel’s scenic Jezreel Valley. At the age of nine, after seeing The Waltz King, the Walt Disney film about Johann Strauss, he wanted nothing more than to play the violin. A short time later he switched over to the viola, finding his true voice, and studied with some of Israel's leading teachers, including Chaim Taub, Gad Lewertoff, and David Chen.

After meeting renowned violist Tabea Zimmermann, he moved to Frankfurt to study with her and later continued his studies with Tatiana Masurenko at the University of Music and Theatre in Leipzig. His performance of Bartók's Viola Concerto under the direction of Daniel Harding, capped his studies there.

He has taken part in international music festivals, including the Lockenhaus Festival, the Young Artist's Festival in Davos, the Spannungen Heimbach Festival, and Prussia Cove, playing alongside artists such as Gidon Kremer, Lisa Batiashvili, Christian tetzlaff, and Menachem Pressler. He was also a member of the Denmark-based Zapolsky String Quartet and the Waldstein Ensemble Wien, performing in many of Europe’s major concert halls, including the Vienna Musikverein, the Concertgebouw in Amsterdam, and London's Wigmore Hall.

As a founding member of the Israeli Chamber Project he has collaborated with many of Israel's most celebrated composers and explored innovative cross-disciplinary projects in Germany, among them with the dance company Sasha Waltz & Guests.

Guy is a frequent guest leader with many of Europe's leading symphony and chamber orchestras, including the Berlin, Stuttgart, and Hamburg radio orchestras, the Deutsche Kammerphilharmonie Bremen, Camerata Salzburg, and Camerata Bern. His Debut solo CD, Monodialogue, was released in 2016 to great critical acclaim.

Between 2006 and 2017 Guy served as viola professor at the Felix Mendelssohn Bartholdy University of Music and Theatre in Leipzig. The 2017-2018 season featured him as a member of the internationally-renowned Pacifica String Quartet and Visiting Professor at the Jacobs School of Music in Bloomington, Indiana. In 2023, he was guest Professor at the Music Academy of Trossingen, and he is currently a visiting professor at the Robert Schumann University of Music and Media in Düsseldorf. He gives masterclasses in Europe, the USA, and Israel.